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Hi, I'm a newbie to this site.
Ok, my history .. will try and keep it brief. Referred for ICSI due to MF but now it's unexplained. We had IVF on our first cycle but due to poor fertilisation we always have ICSI no matter what the analysis is.
1st cycle LP, was due to have ICSI was changed to IVF after EC as semen analysis was better. 9 eggs collected, 3 fertilised but only 1 normally. (300iu Puregon) Ovulated early
2nd cycle ICSI, LP - 8 eggs collected - only 1 egg fertilised (375iu Menopur) Ovulated early again despite later hcg trigger at 35 hours.
3rd cycle ICSI - Short Antagonist with Orgalutran and 300iu Puregon - 11 eggs collectected and 5 fertilised. Trigger was done at 34 hours.
4th cycle ICSI - Short Antagonist with Orgalutran and 300iu Puregon - 9 eggs, 3 of those were immature and 5 fertilised. 34 hour trigger again.
My questions are:
On EC of my 4th cycle my lining had thinned. At my last scan it was 9mm and triple lined and all the way through stimms was thickening okay. I was given HRT to help thicken it before ET. I recently had my follow up and it was suggested that the antagonist protocol can lower oestrogen levels and this may be why it thinned. Cons was quite concerned why this has happened. It hadnt happened on any of my previous cycles including my 3rd cycle. (antagonist)
During my 4th cycle I took aspirin and stopped acupuncture which I had done through my other 3 cycles.
I also had immature eggs on this last cycle, which I hadn't had before as my issue has always been early ovulation. Does this suggest oestrogen problems also?
Cons wants to change protocol to a short protocol without the antagonist. This scares me as I feel it's risky due to my early ovulation, although I do trigger at 34 hours. I am also concerned that the quality won't be there. The antagonist seems to have helped me get better fertilisation, whether that is due to me not losing my better eggs or whether it gives better quality eggs I am not sure. She did suggest I could get one antagonist shot around CD8.
I don't understand if my lining was developing well through my stimms then why would it be the antagonist drug causing the problem, the problem happened after I stopped the drug and triggered.
Could oestrogen levels appear good by having a good lining and not be when blood tests are done? Bloods weren't done on my last cycle as my clinic doesnt do this routinely. It has been suggested that I would be monitored on my next cycle.
Could aspirin have a negative affect on lining?
Sorry ... many questions. I would be grateful of your opinin.
Andi
Ok, my history .. will try and keep it brief. Referred for ICSI due to MF but now it's unexplained. We had IVF on our first cycle but due to poor fertilisation we always have ICSI no matter what the analysis is.
1st cycle LP, was due to have ICSI was changed to IVF after EC as semen analysis was better. 9 eggs collected, 3 fertilised but only 1 normally. (300iu Puregon) Ovulated early
2nd cycle ICSI, LP - 8 eggs collected - only 1 egg fertilised (375iu Menopur) Ovulated early again despite later hcg trigger at 35 hours.
3rd cycle ICSI - Short Antagonist with Orgalutran and 300iu Puregon - 11 eggs collectected and 5 fertilised. Trigger was done at 34 hours.
4th cycle ICSI - Short Antagonist with Orgalutran and 300iu Puregon - 9 eggs, 3 of those were immature and 5 fertilised. 34 hour trigger again.
My questions are:
On EC of my 4th cycle my lining had thinned. At my last scan it was 9mm and triple lined and all the way through stimms was thickening okay. I was given HRT to help thicken it before ET. I recently had my follow up and it was suggested that the antagonist protocol can lower oestrogen levels and this may be why it thinned. Cons was quite concerned why this has happened. It hadnt happened on any of my previous cycles including my 3rd cycle. (antagonist)
During my 4th cycle I took aspirin and stopped acupuncture which I had done through my other 3 cycles.
I also had immature eggs on this last cycle, which I hadn't had before as my issue has always been early ovulation. Does this suggest oestrogen problems also?
Cons wants to change protocol to a short protocol without the antagonist. This scares me as I feel it's risky due to my early ovulation, although I do trigger at 34 hours. I am also concerned that the quality won't be there. The antagonist seems to have helped me get better fertilisation, whether that is due to me not losing my better eggs or whether it gives better quality eggs I am not sure. She did suggest I could get one antagonist shot around CD8.
I don't understand if my lining was developing well through my stimms then why would it be the antagonist drug causing the problem, the problem happened after I stopped the drug and triggered.
Could oestrogen levels appear good by having a good lining and not be when blood tests are done? Bloods weren't done on my last cycle as my clinic doesnt do this routinely. It has been suggested that I would be monitored on my next cycle.
Could aspirin have a negative affect on lining?
Sorry ... many questions. I would be grateful of your opinin.
Andi
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